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Prednisone withdrawal: Symptoms, treatment, and duration
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Even gut contact can cause bleaching, for example, recently with a general that has been used to wash off benzoyl pose-containing hygiene products. Such price are highly reactive. The homolysis is rare induced by heating.
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❾-50%}Prednisone how long until it is out of your system.How Long Does Prednisone Stay In Your System?
Bloating, belly aches, tender to touch belly has anyone else had this tender almost bruise like feeling in their belly? I am now Day 4 off the drug and feel very off and nauseous. Is there any over-the-counter remedy? Will make you more calm too! I am so very grateful for all of you sharing your stories.
I think it was a reaction to an artificially sweetened beverage I drank over a period of several days, during which the rash continued to get worse and spread. I explained this to her and she put me on a 2 week regimen of prednisone. Day 6 and the insomnia, mood swings, the comes and goes at significant levels appetite, crazy levels of anxiety and horrific gastric pains are Hell.
My husband fears me and I am miserable! I am starting a quick-wean tomorrow, as I am currently miserable and do not want any long-term issues. I was put on 50mg daily of prednisone after going into sever anaphylaxis. I was hospitalized for two days and given even more steroids intravenously. After leaving the hospital we had to call a second time a couple days later from the pills. It has been 5 days since my last dose and I am still feeling awful. It feels like your whole body is crawling and rejecting itself.
This is the most awful medication. It feels like your body is shutting down. Neither the doctors nor pharmacists talked about any side effects until after I was hospitalized the second time.
Biggest understatement of the century. Relieved to read these comments and know I am not alone. My first experience with Prednisone when I was 49 for gastric intestinal problems was mild in comparison to this recent experience at Was put on it for 1 week at 20 mg twice a day for allergic reaction to a bug bite.
The first 4 days were tolerable with only positive side effects but day 5 hit me with a bang. Extreme hunger, hyperactive, sore throat, exhaustion but little sleep and unable to settle down, lost my voice and felt like I was crawling out of my skin. It was horrible to say the least. Was very glad to stop it on day 7. I felt horrible for 5 days after stopping this medication… sore throat, runny nose, still extreme hunger, complete exhaustion.
Hi Katelyn. This sounds very similar to my experience that I am dealing with now. How are you feeling today? How long did it take you to return to normal? I had to take a 20 day round dropping down every 5 days. I can walk again, back much better but feeling terrible. I think due to prednisone. I have been on prednisone for two months — started at 60 mg, now tapering down. I currently take 30 mg and will be off the med by the end of three months. It was prescribed for sudden vision loss — optic neuritis is the diagnosis.
My vision has finally started to improve, but I have gained 15 pounds and my face is so swollen it is painful. Wondering how long it will take for the weight to come off and for my face to return to normal. I hate taking medication but had no choice. Question: Have you been tested for Multiple Sclerosis? Optic Neuritis is a common first symptom. I have been on it since June. How long did it take for yours to get better?
I have been on Prednisone 10 mg since January and I completed on March 31st. I still feel bloated and have gained 15 lbs. My eyes are still tearing and I am always exhausted! But, I have been sleeping better meaning continuously.
Today is my last day — thank you Jesus!! By Sunday day 6 I noticed joint pain in front of legs and in left knee, ears feel stopped up, head stuffiness which is exasperating because it is allergies — stuffiness and a clogged right ear that has me on this med to begin with and overall achy. After reading the comments, it seems that there are various side effects, not all the same. Most common is sleep patterns, lethargy, the face puffiness, and appetite and weight gain.
My eyes would get bloodshot and just physically, I would look exhausted. My dr put me on Prednisone on , 20 mg , he said to take 2 a day for 10 days and 1 a day for another 10 days. I had a swollen hand -some type of bacterial infection. I took the last dosage on the 9th, only 17 days because I was feeling so weird. I have moon face and decided today to find out when the heck this and the other symptoms would be going away. Now I find out — who knows? I took this for a week for a sinus infection and then about days later got my period.
When my period first started the cramps felt like someone was gutting me from the inside out and the blood was very light then went heavier and now back to light.
But any advice on how to stop prolonged periods thanks to this would be great.. No one told me the side effects of this when prescribed and I thought I was pregnant or something was wrong with me all week until I found something that mentioned steroids and bam answers came. I would have never taken it if I knew I would get a period and one this bad too!
I wish I found info sooner. Along with dry skin and slight depression. I am so glad I found this page! I was put on a 5 day of 20mg twice a day. I felt really jacked up the first two days, broken sleep, hot and cold so the next two days I just took one.
I had had no appetite, the thought of any food made me nauseous. I started violently vomiting at 11pm til 3am. What I thought was the flu I now believe is a horrible reaction to prednisone after searching the web about reactions. First and last time I will ever take this drug! Worse I have to get on a plane tomorrow with my son in a four hour flight for a college visit.
I was placed on the medrol dose pack for 6 days at 4mg each…day 1 I had to take 6 then taper down each day by 1 less. I have tried everything with drinking water and eating just to flush it out, I even went to the hospital for a saline drip which did nothing. Reading your experience helps me feel not so alone. I took the exact same dose you did and had pretty much the exact same experience.
I took the pack back in February, so around the same time as you. It was the brand Qualitest, in a yellow brown box. Is that the same one you took? Also, how are you feeling now? Hopefully you are feeling back to normal!
I was put in steroid pack for sinuses. By day 4 I was feeling anxious. Doctor told me to stop taking them so I did. Now next day I feel super exhausted and weak. I have to go back to work tomorrow as I missed 4 days of work already. Giving me steroid pack was worst thing the doctor could of done for me and it lowers immune system and we are in flu crazy mode. I had a severe case of hives. They put me on prednisone for 3 days. It calmed my hives down, but day 2 I felt big. Then day 3 I woke up with a red face and feel even bigger.
My taste buds have changed. Nothing tasted good. Praying this is all over. I was on 10mg of prednisone for 30 days. I stopped 2 days ago and I have moon face.
How long before my face returns to normal? I was prescribed 5 days of 20mg of Prednisone for sinusitis, along with Augmentin. Though, I only took 4 days. I am in remission from MCD minimal change disease of the kidneys , yet I am having difficulty walking and getting up from a chair. The kidney doctor has scheduled me once a month for lab work and an office visit every other month for the next year.
I am better and I look forward to changes every day. I was on 80mg of prednisone per day for 16 weeks and a 6 weeks step down to zero. That was 8 months ago and I am really concerned about the after effects. The night after my last dose I felt like I was going to have a heart attack and as though electricity was rushing through my entire body.
I had a fever over degrees for 3 days. It has been over a week since I took my last dose and I still feel very lethargic, I have no energy or appetite. My urine has changed in color and my thoughts are scattered.
This was then extended for a further 3 days plus more antibiotics , then another 7 days followed by tapering off at the rate of 1 tablet every 3 days 5 tabs for 3 days, then 4, then 3 etc. Unfortunately, by the time I was down to 2 tabs 10mg daily my asthma symptoms of excessive wheezing, breathlessness, coughing and exhaustion, all returned with a vengeance and I was put back up to 30mg daily again.
Finally my symptoms diminished and I took the last Prednisolone 10 days ago and the last antibiotic today. But, altogether, I was taking the steroids for about 9 weeks at varying doses. However — I now have steroid-induced diabetes which my GP is expecting me to be stuck with. My symptoms now are increased thirst, dry mouth, waking up times nightly to urinate, banging headaches especially first thing on waking , extreme tiredness and very low mood. And, if so, what was the outcome? I am an asthmatic adult and suffered an asthma attack 5 days ago.
After the salbutamol nebuliser, I was prescribed 30mg of Prednisolone for 5 days along with mg of Clarithromycin twice daily. I took the final dose of Prednisolone about 4 hours ago. I was prescribed mg of Clarithromycin, twice a day at the same time.
I will never take this prescribed medicine again. I was given Prednisone 20mg daily for a fungal infection of lungs. I was given no warning of side effects. After about 4 months I started with extreme thirst and several head calls nightly. I was given Januvia mg daily. I have diabetes ll and do not know if it will go away. I requested to be taken off Prednisone and was tapered down. It has been about 2 weeks and I have the aches and stiffness and down feeling about being diabetic and not knowing what is ahead.
I do not want to offend anyone by talking about my dogs issue. But they mirror your comments. My dog has lymphoma and was put on chemo and a high dose of prednisone daily.
I kept telling the vet of the symptoms of panting, fatigue, she gained 22 pounds in 4 months. Her sweet personality has become aggressive. Her urination was so excessive. Her moist nose dried out. No energy at all. Again, this may vary slightly from person to person, but you can reasonably expect that prednisone will be completely eliminated within a fairly well-defined range of 12 to 18 hours.
As mentioned at the beginning of this article, there are several factors that can influence how long prednisone stays in your system. Perhaps the most significant variable is liver function since it is responsible for prednisone metabolism. If you have decreased liver function, be it from disease or other factors such as old age , you can expect prednisone to be more slowly eliminated.
Similarly, if you take drugs that decrease the activity of certain liver metabolizing enzymes, like CYP3A4, it could take longer for prednisone to be metabolized. Strong inhibitors of CYP3A4 include:. There are many other factors that could influence prednisone metabolism e. Overall though, we can expect 12 to 18 hours to be a fairly accurate estimate.
It is important to note that even though has a fairly short half-life and is eliminated relatively quickly when compared to many other drugs, its biological action lasts much longer. In fact, most sources state that the effects of prednisone last between 18 to 36 hours per dose. This long duration of action is due to the fact that the drug is highly protein bound in the plasma specifically to albumin and transcortin and because it is extensively distributed to various organs in the body e.
It also is important to point out that prednisone itself is not active, but is metabolized in the liver to the active metabolite prednisolone. Prednisolone has a similar half-life to prednisone, around two to three hours. Some of them might, like for example, hunger , It might suddenly just instantly be gone. You might just suddenly have your normal appetite back when you stopped taking it.
But side effects like psychiatric ones— anxiety, and mood changes— might not go away very quickly, and why is this? And for some people, it can take up to a year to really recover back to their formal adrenal-sufficient self. If you are feeling terrible after taking prednisone, then you need to talk to your doctor.
You took me off the prednisone, but I still need some help. Can you help me? You should be able to have the dose taken down slowly enough that you can recover. If you have any other real burning questions behind prednisone half-life, let me know below. I love to know what those are, so I can answer them in either comments or in a future video. And if you need help recovering from prednisone, I have a prednisone checklist, and I will link that below that you can get. Signing off as Dr.
Megan, the Prednisone Pharmacist. You are being redirected to our trusted and authorized Nutranize product website. The Nutranize website is designed, constructed and endorsed by Dr. The doctor may need to readjust their tapering plan or treat any health complications.
To help prevent prednisone withdrawal, a person can take the following precautions while using prednisone and during the taper period afterward:. Most people will recover fully from prednisone withdrawal once their body begins producing enough cortisol again. The duration of symptomatic withdrawal will vary according to the dosage of prednisone that the person was taking and the length of the course of treatment.
Generally, people who were on a lower dose for a shorter period will have less severe symptoms. They may also recover from prednisone withdrawal more quickly, or they may not experience any withdrawal symptoms at all. Prednisone is a steroid that can be used as part of a person's treatment after they have a significant asthma attack.
In this article, we examine the…. Methylprednisolone and prednisone are medications that can treat certain health conditions, such as rheumatoid arthritis, by reducing inflammation in…. Prednisone oral tablet is a prescription drug used to treat inflammation from conditions such as multiple sclerosis and rheumatoid arthritis. Whether a person can drink alcohol while taking prednisone depends on a range of factors, including the length of the treatment.
Learn more here. A person may apply topical steroids to the skin to help control inflammatory skin conditions. However, people may also experience topical steroid…. The amazing story of hepatitis C, from discovery to cure New directions in dementia research Can psychedelics rewire a depressed, anxious brain?
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It takes hours for about half of your prednisone dose to leave your system. First of all, when you might be looking up the term prednisone half-life, what are you really wanting to know? Scroll down to know more! The short answer is the half-life of prednisone is two to three hours. But what does that even mean? A half-life is how long it takes for half of something to be gone.
So if an atomic bomb goes off, how long will it take for half of the radiation to disappear? For example, if you took prednisone 40 milligrams, you took two of these. So you could say after about 18 hours, somewhere, give or take, your body is free of the act of prednisone. So what difference does that make? Well, it has a lot of things that can affect it.
That can help you get more restful sleep. Some doctors will prescribe prednisone to be taken every other day, so you take five milligrams on Monday, skip, take nothing on Tuesday, five milligrams on Wednesday, and that can be happening because of the half-life. Other things that are worth understanding is prednisone is a medium length of time drug, so it lasts two to three hours. Whereas methyl prednisone lasts less time, and then dexamethasone lasts way more time.
It lasts almost like a whole day, its half-life, so it takes a long time for the dexamethasone to get out of your system.
You can usually reliably only have to take prednisone once a day, but hydrocortisone, since it only lasts a few hours, it needs to be taken, for example, right before breakfast, at lunch, and at dinner maybe, or it might be four times a day. It really depends on when you need it, and you work that out with your doctor. A tornado might be a great way to get rid of a building. It just goes in and immediately that building is gone, but what about all the collateral damage?
What about all the other buildings? Oh, and your landscaping, and all of the people and their things that could have been affected. Those are the side effects. I mean, you probably only wanted to take out one building, but it took out a whole city or a whole street or a lot more.
It had all of this damage. Somebody has to plant those trees again. Somebody has to find all of the things that blew away in the storm, and so prednisone side effects do not instantly go away. Some of them might, like for example, hungerIt might suddenly just instantly be gone. You might just suddenly have your normal appetite back when you stopped taking it. But side effects like psychiatric ones— anxiety, and mood changes— might not go away very quickly, and why is this?
And for some people, it can take up to a year to really recover back to their formal adrenal-sufficient self. If you are feeling terrible after taking prednisone, then you need to talk to your doctor. You took me off the prednisone, but I still need some help.
Can you help me? You should be able to have the dose taken down slowly enough that you can recover. If you have any other real burning questions behind prednisone half-life, let me know below. I love to know what those are, so I can answer them in either comments or in a future video. And if you need help recovering from prednisone, I have a prednisone checklist, and I will link that below that you can get.
Signing off as Dr. Megan, the Prednisone Pharmacist. You are being redirected to our trusted and authorized Nutranize product website. The Nutranize website is designed, constructed and endorsed by Dr. Megan Milne, the Prednisone Pharmacist. Please grant us just a few seconds to get you there. What is a Half-Life? What you really probably want to know is, when am I going to feel better? When is it going to be out of my system? But how many half-lives matter? When Should You Take Prednisone?
How Long Does Prednisone Last? So, I promised the answer to the real question. There are so many side effects. Talk to your Doctor If you are feeling terrible after taking prednisone, then you need to talk to your doctor. Free Prednisone Checklist. This field is for validation purposes and should be left unchanged. Send My Prednisone Checklist.
When to take Calcium with Thyroid Medicine? Can Prednisone Affect your Thyroid? Can prednisone affect your thyroid? Yes, prednisone can affect your thyroid. Does Prednisone Shrink Your Brain? Does prednisone shrink your brain? You are being taken to my store.
localhost › medical-answers › prednisone-how-long-does-it-take-pr. You could expect a dose of prednisone to stay in your system for to 22 hours. The elimination half life of prednisone is around 3 to 4. blood pressure; memory; reducing inflammation. ADVERTISEMENT. Online therapy can help with long-term addiction support. Prednisone leaves the body in about a day, however, the effects of steroids last several days. A person should never need a prednisone detox as. Psychological withdrawal symptoms could last for 2 to 8 weeks. The doctor may give you blood tests to check your cortisol levels as you taper. I became nervous, panic and feeling so crazy. Megan, the Prednisone Pharmacist. To help prevent prednisone withdrawal, a person can take the following precautions while using prednisone and during the taper period afterward:. It helped with the reaction half way. Doctor told me to stop taking them so I did.Prednisone is a common synthetic corticosteroid medication that was initially synthesized in In addition to being an anti-inflammatory agent, prednisone is an effective immunosuppressant drug, exerting effects by modifying gene transcription, reducing activity within the lymphatic system e.
T-lymphocytes , decreasing levels of immunoglobulin, and minimizing travel of immune complexes through basement membranes. Though prednisone is an extremely helpful medication when no other treatments are available, it is akin to using a pill-based atomic bomb; it may effectively hit the target treat the medical condition , but there are often other casualties severe adverse effects incurred throughout the process.
Since treatment-induced adverse effects can linger well-after a person has discontinued treatment, many wonder whether prednisone is still in their system after stopping and for how long.
To determine how long Prednisone stays in your system after stopping, it is important to consider its half-life. If considering the 2 to 3 hour documented half-life, the Prednisone should theoretically be cleared from your system between 11 and This would indicate that elimination of prednisolone concentrations from systemic circulation would take just under 20 hours.
In other words, both Prednisone and prednisolone should be cleared from your body within a 24 hour period after stopping. Prednisolone facilitates numerous physiological alterations throughout your body that could linger for a long-term following discontinuation.
Some people are thought to clear the drug significantly faster than 17 to 20 hours, whereas others may be unable to clear it for over 24 hours after their last dose. Variables such as: individual attributes, Prednisone dosage, term of administration, and co-ingestion of other drugs — account for differences in clearance speed. Two people could begin taking prednisone at the exact same time, with the same dose and format, and cease usage in sync — yet one person may clear the drug quicker than the other individual.
Age : There may be differences in clearance times of prednisone and prednisolone among young adults compared to elderly. For this reason, the elimination time of Prednisone could be prolonged among those over Some research suggests that young children may also exhibit differences in clearance speed of prednisolone compared to adolescents and adults. The half-life of prednisolone is thought to be an average of 3.
The elimination half-life of prednisolone and prednisone among healthy adults is 2 to 3 hours. More massive individuals can usually handle a slightly greater amount of an exogenous substance compared to smaller people.
However, prednisolone is metabolized by CYP3A4 enzymes within the liver. CYP3A4 enzymes are thought to be influenced by various genes, resulting in rapid or poor metabolism of the drug. Individuals with specific CYP3A4 alleles may metabolize prednisolone faster than those with different alleles. As a result of expedited metabolism, the drug may get cleared quicker from systemic circulation.
On the other hand, poor metabolizers of prednisolone may take substantially longer to clear it from their system. Food intake : Though medical documentation suggests taking Prednisone with food to avoid gastrointestinal distress, there is evidence that absorption of prednisolone may be affected.
One study noted that taking enteric-coated prednisolone tablets along with food could delay absorption by nearly 12 hours, resulting in prolonged drug retention following ingestion.
If food does in fact delay Prednisone absorption by several hours, the drug will be metabolized at a later time than had a person taken it on an empty stomach. Assuming you ate a large meal with your final dose of Prednisone, realize that it may not be excreted as quickly as had you taken it in a fasted state. Not only does hepatic impairment interfere with the conversion of Prednisone to prednisolone, but it interferes with the metabolism of prednisolone.
The half-life of Prednisolone is noted as being as being as high as This means that complete systemic clearance could take 2. Additionally, renal impairment are known to excrete prednisone and its metabolites at a slower rate than those with normative kidney function.
BMR is influenced by a variety of factors such as genetics, exercise habits, dietary intake, and sleep. Realize that metabolic rate may not have a significant effect on excretion time, but it could facilitate differences in clearance times potentially by minutes or hours.
Oral contraceptives : Women taking oral contraceptives may interfere with the enzymatic metabolism of both Prednisone and prednisolone in the liver. Oral contraceptives typically contain an estrogenic component, affecting hepatic enzyme activation and plasma proteins. Co-ingestion of an oral contraceptive along with Prednisone increases peak serum concentrations and its elimination half-life.
The ingestion of oral contraceptives results in poorer non-renal clearance of prednisolone and reduced binding of prednisolone to albumin and transcortin. If you take contraceptives along with prednisone, it could linger in your system for up to 22 hours after your final dose. Urinary pH : Prednisone is metabolized in the liver, processed by the kidneys, and excreted in the urine as free and conjugated metabolites.
Individuals with alkaline urine high pH tend to excrete substances like Prednisone less efficiently than those with acidic urine low pH ; acidification of urine prevents reabsorption prior to excretion, whereas alkaline urine allows it. The greater the dosage of Prednisone someone takes, the longer it will stay in their system. As a result, someone taking Prednisone at a dosage of 80 mg per day will metabolize and excrete it at a slower rate than someone taking just 10 mg per day.
Furthermore, the lower dose user taking 10 mg will only have 5 mg in systemic circulation after hours, whereas the individual who took 80 mg will have 40 mg remaining in circulation after hours.
In addition, a greater amount of prednisolone metabolites will be formed in the system of a person taking a higher dose. Research has shown that changes in the elimination half-life of the prednisolone metabolite are dose-dependent.
For this reason, it is thought that clearance time in an extremely short-term user will be considerably less than that of a long-term Prednisone user. Simultaneously taking other drugs or supplements along with Prednisone could affect its metabolism and excretion.
Drugs that affect CYP3A4 isoenzymes in the liver are thought to have the greatest impact on prednisolone clearance. Should a person ingest any of these agents along with Prednisone, they may significantly increase the elimination half-life of prednisolone — thus taking longer to clear from your system. Should you be taking any of these substances along with Prednisone, the half-life of prednisolone may be reduced.
Following oral administration of Prednisone, it is efficiently absorbed by the gastrointestinal GI tract. Prior to its conversion to prednsiolone, Prednisone has a half-life of just 1 hour.
However, post-conversion to prednisolone, its half-life is extended between 2 to 4 hours. Prednisone binds to plasma proteins such as albumin and serum concentrations peak within hours post-administration. Peak concentrations are followed by an exponential decrease in serum levels after 2 hours. Hepatic enzymes facilitate additional breakdown of prednisolone to form metabolites such as: prednisone oxo metabolite , 6-Beta-OH-prednisolone, Beta-OH-prednisolone, Alpha-OH-prednisolone, Alpha-OH-prednisone, Beta-OH-prednisone, and various tetrahydro epimers of each.
A total of 10 metabolites have been identified from prednisolone metabolism. Prior to excretion, metabolites undergo glucuronidation or are coupled with sulfate via 3-hydroxyl. The drug is excreted via urine as free and conjugated metabolites along with unchanged prednisolone. The half-life of Prednisone is 2 to 4 hours, meaning a majority of the drug and its metabolites will have been excreted within 24 hours after your final dose.
Note : There is a slight difference in peak maximum serum concentration in delayed-release Prednisone formats. Delayed-release formats are estimated to reach a maximum serum concentration in approximately 6. This is substantially longer than immediate-release Prednisone which reaches peak concentrations within 2 hours.
That said, due to its short half-life, the drug should be out of systemic circulation within 24 hours of your final dose. Any of the tips listed below should be discussed with a medical professional prior to implementation.
Do you think that the drug and its metabolites are mostly excreted within 24 hours after your last dose? If you believe that Prednisone stays in your system for much longer than is suggested in medical reports, do you have any credible scientific evidence to support your claims?
In reality, the side effects are lingering because of the potent physiological effects that were exerted when Prednisone was in the body — not because it is still present. Think of Prednisone as analogous to a tornado going through a city and wreckage as lingering side effects. Even though the tornado has passed and is gone Prednisone is out of the system , the deleterious effects take awhile before they are corrected. In other words, after stopping Prednisone, it takes time for the wreckage to get fixed adverse effects to subside.
Know that for most people, Prednisone should be out of the body within a day or two of stopping. I was prescribed Prednisone for a lower quad tendinitis injury.
I needed it to help an injury before a major race. I have had sleeplessness, elevated heart rate, loss of appetite and brain fog. My race is in three days. I am worried that the side effects may hinder my performance even worse than my knee. On a Saturday I was admitted to our local hospital. Diagnosis was bronchial pneumonia. I had every side effect that comes with taking it. While in the hospital I kept telling the doc my vision had gotten horrible… Blurry.
After researching I found it could be the prednisone. If I found out outs permanently affected my vision. Someone will pay!! How scary. So sorry you are going through this.
He insisted I take it I took 60 mg today. My pulse is ridiculously high resting walking and when I was sitting outside earlier my eyes were bothering me. Things were blurry. I felt dizzy. Best of luck to you. I have been taking a low dosage for Poison Ivy and I am currently weening off slowly, 4 more days to go. Hope the side effects are not too bad. I am feeling slightly dizzy during the day, but nothing I cannot handle.
After reading such bad reactions I hope you all make a full recovery. I came in contact with something that sent me into a severe allergic reaction with thick hives covering me from my scalp to the bottom of my feet.
I was put on steroids 25mg twice a for 2 weeks then 1 a day for a week, plus benadryl pills 50 mg every 4 hours until I cleared up and then as needed. My thoughts are racing faster than I can process them.
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