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Differin Gel & Cream - NPS MedicineWise
Differin (Adapalene) for Acne: What To Know - Thinking about buying the over-the-counter retinoid Differin (adapalene)? Read this first.
It does not contain all the available information. It does not use the place of talking to your doctor or pharmacist. All medicines have risks and benefits. The product acts against the abnormal skin processes associated with acne. If it has expired or is damaged, return it to your pharmacist for disposal. Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes. DIFFERIN gel contains methyl hydroxybenzoate E which may cause allergic reactions possibly delayed and propylene glycol which can cause skin irritation.
Tell your doctor if you are pregnant or plan to become pregnant. Your doctor can discuss with you the risks and benefits involved. Tell your doctor if you are breast-feeding or planning to breast-feed. Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.
Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine. Ensure that the affected areas are dry before application. Ask your doctor or pharmacist if you are not sure how much to apply. They will tell you exactly how much to use for each application. Avoid the use of of oil-based makeups and creams. Cosmetic products with an abrasive, drying or peeling action may cause an extra irritant effect.
Pimples and spots will be reduced only after several application of this medicine. It may take weeks to notice an improvement and more improvement after further use. If it is almost time for your next dose, skip the dose you missed and use your next dose when you are meant to. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Otherwise, your doctor may think that it was not effective and change your treatment unnecessarily.
Minimise exposure to sunlight and UV lamps. Protect your skin when you are in the sun, especially between 10 am and 3 pm. All medicines may have some unwanted side effects.
Sometimes they are serious, but most of the time they are not. Your doctor has weighed the risks of using this medicine against the benefits they expect it will have for you. Do not be alarmed by this list of possible side effects. You may not experience any of them. Tell your doctor as soon as possible if you notice any of the following and they worry you:.
If you experience sensitivity or irritation when applying this medicine, stop using it and tell your doctor. You may be asked to use the cream less often, or to stop using it until symptoms subside. These are very serious side effects.
You may need urgent medical attention or hospitalisation. Tell your doctor if you notice anything else that is making you feel unwell. Other side effects not listed above may occur in some patients. If you have queries about any aspect of your medicine, or any questions regarding the information in this leaflet, discuss them with your doctor or pharmacist. Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
It is supplied in plastic tube with a plastic cap containing 3g, 5g, 30 g and 50g of cream or 5g, 30g and 50g of gel. Excipients with known effect. Methyl hydroxybenzoate, propyl hydroxybenzoate. For the full list of excipients see Section 6. Topical treatment of comedo, papular and pustular acne acne vulgaris of the face, chest or back. A thin film of Differin Topical cream should be applied to the affected areas once a day before bedtime and after washing avoiding the eyes, lips and mucous membranes.
The affected areas should be dry before application. Clinical improvement is expected to be evident in 4 to 8 weeks of treatment, with further improvement to be expected with continued use.
Cutaneous safety of Differin topical cream has been demonstrated in patients for up to 12 weeks of treatment. Since it is customary to alternate therapies in the treatment of acne vulgaris, it is recommended that the physician assess continued treatment of the patient with Differin topical cream after 3 months of use.
Not to be used in patients who are hypersensitive to the active substance or any of the excipients. For external use only. Differin Topical Cream should not come into contact with the eyes, lips, mouth and mucous membranes, angles of the nose or broken skin cuts and abrasionssunburn or eczematous skin, nor should it be used in patients with severe acne involving large areas of the body.
If product enters the eye, wash immediately with warm water. Because of a potential for increased irritation Differin Cream should not be used by patients with eczema, seborrhoeic dermatitis or severe acne involving large areas of the body.
If a reaction suggesting severe irritation occurs, discontinue use of the medication. If the irritation is not severe, use the medication less frequently, discontinue use temporarily until symptoms subside, or discontinue use altogether.
If patients use cosmetics, these should be noncomedogenic and nonastringent. Only oil free moisturisers should be used to relieve dry facial skin.
Because Differin Topical cream may cause some irritation, it is possible that simultaneous use of abrasive cleansers, astringents or strong drying agents or irritant products may cause additive irritant effects.
Animal studies on compounds with a similar mode of action to adapalene have suggested that these may enhance the development of skin cancers caused by UV light.
Adapalene is essentially stable to oxygen and light and is chemically nonreactive. Whilst short-term studies have shown no phototoxic to photoallergic potential of adapalene, small numbers of reactions consistent with phototoxicity were reported in clinical studies.
The safety of using adapalene during long or repeated exposures to sunlight or UV radiation has not been established in animals or humans. Exposure to sunlight or UV irradiation including sunlamps should be avoided during treatment with adapalene. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided.
Efficacy and safety in the treatment of severe pustular or deep cystic acne acne conglobata have not been studied. Differin Cream contains methyl hydroxybenzoate E and propyl hydroxybenzoate E that can cause allergic reactions can arise after the treatment is completed. Use in the elderly. No data available. Paediatric use. Safety and efficacy in children below the age of 12 years have not been studied. Effects on laboratory tests.
There are no known interactions with other medications which might be used topically and concurrently with Differin Topical Cream; however other retinoids or drugs with a similar mode of action should not be used concurrently with adapalene. Exposure of adapalene to other topical antiacne drugs such as erythromycin, clindamycin phosphate or benzoyl peroxide does not produce any mutual degradation.
Absorption of adapalene through human skin is low see Section 5. Differin topical cream has potential for local irritation and it is possible that concomitant use of peeling agents, astringents or irritant products may produce additive irritant effects. Effects on fertility. In addition the incidences of various skeletal variations were increased at lower oral doses in rats. Because of the risk of teratogenicity shown in animals, and since there are no adequately controlled studies in pregnant women, adapalene should not be used by women who are pregnant or who plan to become pregnant during treatment.
In case of unexpected pregnancy, treatment should be discontinued. It is not known whether adapalene is excreted in human milk. Therefore, the preparation should be used with caution in nursing mothers, and only on areas away from the chest. Cautionary use of Differin during breast feeding should avoid contact exposure of the infant, application of Differin to the chest should be avoided when used during breast-feeding. The effects of this medicine on a person's ability to drive and use machines were not assessed as part of its registration.
A feeling of warmth, burning, pruritus, dryness, scaling or slight stinging may occur following application. Local adverse events may persist despite cessation of therapy. No systemic reactions have been attributed to the application of the cream to date. The allergic potential of adapalene has not been established. Side effects. Redness, dry skin, burning sensation at the site of application and scaling.
Skin irritation, pruritus and sunburn. Most reactions occurred within 1 month of the initiation of therapy and were generally observed to resolve with continued use of the product or temporary adjustment of the treatment schedule. See Table 1. Postmarketing data. Differin Cream 0. The gel formulation was first marketed in France in September The postmarketing data detailed below refer to reports collected from the worldwide sales with the gel formulation.
Body as a whole.
❾-50%}Why Differin gel is one of the best anti-aging products - TODAY.Differin Gel Review: Everything to Know About The Acne Treatment
It might not be edible, but this kind of sandwich is sure to be an excellent anti-aging treat for your skin. IE 11 is not supported. For an optimal experience visit our site on another browser. Today Logo. Share this —. Follow today. Differin 0. Slide 1 of 2. Note: Benzoyl peroxide can cause your retinoid to oxidize and become less effective, and salicylic acid can be irritating.
If you're dealing with an active pimple, you should hold off on Differin while you spot-treat. In addition to salicylic acid and benzoyl peroxide, you shouldn't apply Differin while also using products that contain chemical exfoliators think: glycolic and alpha-hydroxy acids or drying agents astringents and toners, for example.
Like retinoids, exfoliators increase cell turnover, but too much exfoliation can lead to raw, irritated skin. Toners, meanwhile, can be too drying when used along with a retinoid. Instead, follow Differin with an ultra-rich moisturizer that will calm irritation and deliver much-needed hydration. Flaky skin, redness, itchiness, and irritation are common side effects of Differin, experts said. Shamban noted. To ease the transition, she recommended starting out by using a very small amount of the formula, followed by a moisturizer to combat flaking.
Start every other day and work your way up to nightly use as your skin builds tolerance. While Differin is well known and FDA-approved for treating acne, it shouldn't be discounted as an anti-ager. When the FDA approved the gel in , the organization advised people who are pregnant, trying to get pregnant, or are breastfeeding to not use Differin. Some studies had linked other retinoids to birth defects, and there weren't enough good studies on adapalene to deem it safe for pregnancy.
As of July , the FDA hadn't released an updated guidance. The American Academy of Dermatology recommended to stop using adapalene during pregnancy. Topical treatment of comedo, papular and pustular acne acne vulgaris of the face, chest or back. A thin film of Differin Topical cream should be applied to the affected areas once a day before bedtime and after washing avoiding the eyes, lips and mucous membranes. The affected areas should be dry before application.
Clinical improvement is expected to be evident in 4 to 8 weeks of treatment, with further improvement to be expected with continued use. Cutaneous safety of Differin topical cream has been demonstrated in patients for up to 12 weeks of treatment.
Since it is customary to alternate therapies in the treatment of acne vulgaris, it is recommended that the physician assess continued treatment of the patient with Differin topical cream after 3 months of use. Not to be used in patients who are hypersensitive to the active substance or any of the excipients.
For external use only. Differin Topical Cream should not come into contact with the eyes, lips, mouth and mucous membranes, angles of the nose or broken skin cuts and abrasions , sunburn or eczematous skin, nor should it be used in patients with severe acne involving large areas of the body.
If product enters the eye, wash immediately with warm water. Because of a potential for increased irritation Differin Cream should not be used by patients with eczema, seborrhoeic dermatitis or severe acne involving large areas of the body. If a reaction suggesting severe irritation occurs, discontinue use of the medication.
If the irritation is not severe, use the medication less frequently, discontinue use temporarily until symptoms subside, or discontinue use altogether. If patients use cosmetics, these should be noncomedogenic and nonastringent.
Only oil free moisturisers should be used to relieve dry facial skin. Because Differin Topical cream may cause some irritation, it is possible that simultaneous use of abrasive cleansers, astringents or strong drying agents or irritant products may cause additive irritant effects. Animal studies on compounds with a similar mode of action to adapalene have suggested that these may enhance the development of skin cancers caused by UV light.
Adapalene is essentially stable to oxygen and light and is chemically nonreactive. Whilst short-term studies have shown no phototoxic to photoallergic potential of adapalene, small numbers of reactions consistent with phototoxicity were reported in clinical studies. The safety of using adapalene during long or repeated exposures to sunlight or UV radiation has not been established in animals or humans. Exposure to sunlight or UV irradiation including sunlamps should be avoided during treatment with adapalene.
Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Efficacy and safety in the treatment of severe pustular or deep cystic acne acne conglobata have not been studied. Differin Cream contains methyl hydroxybenzoate E and propyl hydroxybenzoate E that can cause allergic reactions can arise after the treatment is completed. Use in the elderly. No data available. Paediatric use. Safety and efficacy in children below the age of 12 years have not been studied.
Effects on laboratory tests. There are no known interactions with other medications which might be used topically and concurrently with Differin Topical Cream; however other retinoids or drugs with a similar mode of action should not be used concurrently with adapalene.
Exposure of adapalene to other topical antiacne drugs such as erythromycin, clindamycin phosphate or benzoyl peroxide does not produce any mutual degradation. Absorption of adapalene through human skin is low see Section 5.
Differin topical cream has potential for local irritation and it is possible that concomitant use of peeling agents, astringents or irritant products may produce additive irritant effects. Effects on fertility. In addition the incidences of various skeletal variations were increased at lower oral doses in rats.
Because of the risk of teratogenicity shown in animals, and since there are no adequately controlled studies in pregnant women, adapalene should not be used by women who are pregnant or who plan to become pregnant during treatment. In case of unexpected pregnancy, treatment should be discontinued. It is not known whether adapalene is excreted in human milk. Therefore, the preparation should be used with caution in nursing mothers, and only on areas away from the chest.
Cautionary use of Differin during breast feeding should avoid contact exposure of the infant, application of Differin to the chest should be avoided when used during breast-feeding. The effects of this medicine on a person's ability to drive and use machines were not assessed as part of its registration.
A feeling of warmth, burning, pruritus, dryness, scaling or slight stinging may occur following application. Local adverse events may persist despite cessation of therapy. No systemic reactions have been attributed to the application of the cream to date. The allergic potential of adapalene has not been established. Side effects. Redness, dry skin, burning sensation at the site of application and scaling. Skin irritation, pruritus and sunburn.
Most reactions occurred within 1 month of the initiation of therapy and were generally observed to resolve with continued use of the product or temporary adjustment of the treatment schedule.
See Table 1. Postmarketing data. Differin Cream 0. The gel formulation was first marketed in France in September The postmarketing data detailed below refer to reports collected from the worldwide sales with the gel formulation. Body as a whole. Immune system disorders. Skin and subcutaneous tissue disorders. These events often spontaneously resolve upon adaptation to therapy regimen.
Reporting suspected adverse effects. Reporting suspected adverse reactions after registration of the medicinal product is important. It allows continued monitoring of the benefit-risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions at www. Differin Topical cream is intended for topical use only. If the medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling or discomfort may occur.
Differin topical cream is not to be taken orally. Unless the amount accidentally ingested is small, an appropriate method of gastric emptying should be considered. For information on the management of overdose, contact the Poisons Information Centre on Australia.
We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission. This topical medication contains adapalene, a form of retinoid derived from vitamin Athat has been found to slow the process of excessive growth in the lining of pores and desensitize the skin to inflammation.
This makes it an excellent treatment for acne. The gel contains 0. Differin Gel is the first acne treatment the FDA approved in more than 30 years.
Adapalene has been used to treat acne for more than 20 years. Retinoid is a compound of vitamin A, which helps regulate cell turnover.
This means it helps with the shedding of the initial layer of skin cells to promote the production of new, healthy skin. In addition, this fat-soluble retinoid penetrates the skin cells and, according to researchit reduces water loss and protects collagen a protein in your body that improves skin elasticity from degradation. Differin Gel was launched in and is available widely in U.
There are other products on the market that contain adapalene. For example, Proactive sells an adapalene gel, as does La Roche Posayneither of which requires a prescription. Both of these gels are comparable in price to Differin Gel and use the 0.
Differin Gel treats acne vulgarisa chronic inflammatory disease of the pilosebaceous unit, which contains the hair follicle and sebaceous gland. Acne may be caused by a variety of reasons, including:. Differin Gel also works by allowing those oils to escape faster. This is your body adjusting to a new regimen. The clogged pores will eventually get pushed to the surface because of cell turnover. Prior to applying Differin to the skin, you should wash your face with a mild and non-irritating cleanser.
After that, you can apply a thin layer of Differin Gel to dry skin and follow up with a moisturizer. If you decide to integrate it into your morning skin care routine, allow it to dry before applying SPF.
You should also try to apply it at the same time every day. Differin Gel is not covered by insurance. An FSA is arranged through your employer and allows the purchase of certain goods tax-free. Mild redness and irritation are commonly experienced within the first 4 weeks. Doctors refer to this as retinization, the process in which your skin begins to adjust to new levels of vitamin A. These symptoms usually peak around 2 to 4 weeks.
You can use a mild moisturizer to lessen some dryness. Like adapalene, tretinoin has also been found to improve the appearance of wrinkles, fine lines, and dark spots.
Tretinoin is a form of retinoic acid and is also known as Retin-A. The prescription-strength topical cream works by irritating the skin and speeding up the life cycle of skin cells.
It makes the cells divide and die faster, promoting the production of newer and healthier cells. Tretinoin is a synthetic version of vitamin A. Tretinoin is also used topically. You should wash your face and wait 20 to 30 minutes before applying the medication to the specific areas that you need it. Differin Gel has been widely reviewed by consumers. On Amazon alone, Differin Gel has more than 42, reviews and maintains a 4.
Other reviewers talk about skin dryness that accompanies Differin Gel use. Others warn that dryness may increase if you apply it right after washing your face.
The complaints on the Better Business Bureau disclose instances of reimbursement challenges. Most appear to be rectified. The short answer is yes. Most dermatologists love and recommend Differin Gel, and the slew of positive reviews probably speak for themselves.
Additionally, as an older study pointed out, Differin Gel is a good option for people who have had acne and are looking for a product that will help prevent future acne.
While this study examined a stronger suspension of adapalene, the results showed reduced scarring in patients who used this treatment over a 4-month period. During the first few weeks of using Differin Gel, your acne might appear worse because the medication is working on pimples forming inside the skin. You should notice Differin Gel working after 12 weeks of consistent use.
It helps to reduce the appearance of post-acne marks, hyperpigmentation, blotches, age spots, and even freckles. Acne is a very common but difficult condition to treat. InDifferin Gel was approved for sales over the counter.
The 0. It can also help minimize scarring and improve skin texture. For Differin Gel to be effective, it must be used consistently and for an ongoing period of time, usually 3 months. Tracee Herbaugh is a writer and journalist who lives in the Boston area. She writes about culture, lifestyle, health, and family relationships. You can view her work online or find her on Twitter. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.
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There are treatments and skin care habits that can help. How Well Do You Sleep? Herbaugh — Updated on August 19, Less irritating than other retinoids: Similar types, like Retin-A, work significantly faster, but can cause skin inflammation. May reduce the appearance of fine lines and acne scars: Early studies showed the formula may have a hand in doing more than just clearing up acne. Easy application: You only need to apply a pea-size amount at night.
Can irritate skin: Studies have found that a common side effect is sensitivity to sunlight. May make acne worse: Some users report an increase in acne when starting out with Differin Gel. May also cause dry skin: Other users find that their skin became dry with regular use. What is Differin Gel? How does Differin Gel work? How to use Differin Gel.
How can I get Differin Gel? How much does Differin Gel cost? Who should use Differin Gel? What are the side effects of Differin Gel? Differin Gel vs. Tretinoin Cream. Reputation and reviews.
Frequently asked questions. How we vetted this article: Sources. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations.
We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Aug 19, By Tracee M.
localhost › adapalene-topical-route › proper-use › drg Absolutely not. It's a common, temporary reaction that will usually subside after about 4 weeks of use. Use of Differin Gel should not be discontinued, but be. localhost › adapalene-topical-route › proper-use › drg Apply a thin film of DIFFERIN gel or cream to the affected area once a day before bedtime and after washing. Ensure that the affected areas are dry before. That's the good part. What makes Differin a tough sell is that it doesn't work terribly quickly. In fact, two months might pass until you start. There were low quantities of the parent substance in the faeces. It is not known whether adapalene is excreted in human milk. Differin Gel vs.Differin's 0. Popular for being a powerful acne treatment, the benefits of Differin go far beyond erasing blackheads and obliterating pimples. According to Dr. Mohiba Tareen , a board-certified dermatologist, Differin's hero ingredient — adapalene, a type of retinoid — also fights the classic signs of aging: fine lines, dark spots and dull skin. Skin care products with retinol are found everywhere, but Differin is the lone retinoid available without a prescription.
Compared to retinols , retinoids are the stronger, fast-acting sister product, explained Dr. Levin says topical retinoids such as Differin come from vitamin A and help normalize skin cell turnover, which also prevents clogged pores to treat and prevent acne.
It's also the same ingredient that helps improve skin discoloration, texture and tone. Another reason this product is excellent for anti-aging is its gentle yet efficacious formulation, according to Dr.
Adarsh Vijay Mudgil, a board-certified dermatologist. Adapalene is not as irritating as most retinoids, so patients can use this more frequently. Tareen recommends using the gel at night once or twice a week at first, then slowly building up to more frequent use over a few weeks.
The reason being that retinoids can severely dry out your skin! Tareen says anything from CeraVe or Cetaphil will work for this. Then, apply the product and another layer of moisturizer after. It might not be edible, but this kind of sandwich is sure to be an excellent anti-aging treat for your skin. IE 11 is not supported. For an optimal experience visit our site on another browser. Today Logo. Share this —. Follow today. Differin 0. Slide 1 of 2.
Shop How to create a skin care routine for your 40s, according to dermatologists. Summer Cartwright.
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